โ Scribed by S. K. Wahba; S. W. Amin; Nazmy Rofael
No coin nor oath required. For personal study only.
A chromatographic separation of the decomposition products of dexamethasone in tablet form was achieved by using thin-layer chromatography. S ecuophotometric and quantitative colorimetric analyses were run. A stable &let formula has been suggested. HE ANTI-INFLAMATORY corticosteroids repre-EXPERIMENTAL Materials-(a) Dexamethasone (Roussel). The sample was purified by recrystallization from ether. Purity was confirmed by physicochemical means. m.p. 263", infrared, ultraviolet absorption. ( b ) Polyvinylpyrrolidone (Kollidon-25, Badische Anilin and Soda Fabrik). (G) 2,3,5-Triphenyl tetrazolium chloride m reanal-Hungary).
( d ) Talc, lactose, starch, magnesium stearate, Cellulose acetate phthalate, carboxymethylcellulose, acetone, ethyl alcohol, methyl alcohol, chloroform, sulfuric acid, Silica Gel G, all from the British Drug House and of analytical grade.
ProcedureThin-Layer Chromatography-Methanolic and chloroformic extracts of dexamethasone tablets were spotted beside methanolic and chloro-Received August 23. 1967, from the Drug Research and Control Center, The Egyptian Organization For Pharmaceuticals, Chemicals and Medical Appliances, Cairo, U.A.R.
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