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Study of the clinical thermoluminescent dosimeter in the direct measurement of radiation absorbed dose for radioimmunotherapy

✍ Scribed by Rei K. Chiou; Barry W. Wessels; Mildred Woodson; Catherine Limas

Publisher
Elsevier Science
Year
1991
Weight
667 KB
Volume
42
Category
Article
ISSN
0883-2889

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✦ Synopsis

One of the major obstacles facing radioimmunotherapy (RIT) is the lack of a device to measure directly tumor and normal tissue radiation absorbed dose. Calculations based on the clearance and imaging scans have several limitations; hence we design and fabricate a sheathed clinical thermoluminescent dosimeter (TLD) for the measurement of absorbed dose by implantation in humans. Preclinical studies are performed in nine normal rabbits. Complete blood count, body temperature monitoring, clinical observation and necropsy show no untoward effects from the TLD. Consistent bone marrow radiation doses are noted in the four rabbits receiving 131I-labeled monoclonal antibody A6H. By using up to 20 clinical TLDs in one sheath, it will be possible to determine macroscopic heterogeneities in organs undergoing RIT.

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