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Study of the Chemoselectivity in the Aminolysis Reaction of Methyl Acrylate Catalysed by Lipase B from Candida antarctica

✍ Scribed by Oliver Torre; Vicente Gotor-Fernández; Ignacio Alfonso; Luis Fernando García-Alles; Vicente Gotor

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
217 KB
Volume
347
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

The aminolysis reaction of methyl acrylate (MA) with N,N‐dimethyl‐1,3‐propanediamine (DMAPA) in organic solvents has been optimised using lipase B from Candida antarctica (CAL‐B) as biocatalyst. A kinetic study about the influence of the reactant concentrations, organic solvent, temperature and enzyme form has been developed focused on minimising the formation of the Michael addition products. The economic efficiency of this process has been finally investigated by reusing the enzyme in the best reaction conditions, thereby observing no significant loss of activity after three reaction cycles.

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