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Study of the association between major histocompatibility complex class II genes and the response to interferon alpha in patients with chronic hepatitis C infection

✍ Scribed by Laurent Alric; Jacques Izopet; Marylise Fort; Jean-Pierre Vinel; Patrick Fontenelle; Claudine Orfila; Jean-Louis Payen; K Sandres; Herve Desmorat; Jean-Paul Charlet; Michel Duffaut; Michel Abbal


Book ID
117415861
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
208 KB
Volume
60
Category
Article
ISSN
0198-8859

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Combination treatment with pegylated-interferon-alpha (PEG IFN-␣) and ribavirin, the current recommended therapy for chronic hepatitis C virus (HCV) infection, results in a sustained virological response (SVR) in only about half of patients. Because genes involved in the interferon-alpha pathway may