β Scribed by Swartz, Charles J. ;Autian, John
No coin nor oath required. For personal study only.
Solutions of sulfadiazine sodium undergo discoloration and precipitation on prolonged storage. In this study, the nature of the coloration and precipitation has been investigated utilizing infrared and ultraviolet spectroscopic data together with chemical procedures. The coloration was believed to be composed of sulfanilic-type intermedate oxidation products. The precipitate was ascertained to be principally sulfadiazine contaminated with trace quantities of oxidized materials. Experimental evidence is presented to support the above assumptions concerning these degradation products.
N PREVIOUS WORK (1, 2), Hom and Autian I studied the solubility of sulfadiazine sodium as a function of pH in several solvent systems as well as studying the stability of these formulations. The primary products of deterioration, detected by the coloration and preapitation which form on long standing in sulfadiazine sodium injections, were still unknown.
Numerous investigators (3-5) have studied oxidized or other degradated materials from various sulfonamide solutions but little information concerning sulfadiazine sodium was included.
It was furthermore felt that a quantitative study of the deterioration might shed further light on the process which has been concluded to be one of oxidation(3). Therefore, a study employing five distinct measurements of activity was initiated on samples stored in diffused light at room temperature (20-24O) and those stored at 60.0 f 0 . 1 ' in an oven. This study extended over a one hundred day period.
Investigation of Precipitate.-Precipitated material from the deteriorated ampuls was separated by filtration and subsequently washed with several *
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