✦ LIBER ✦

Study of quadrant high-dose intraoperative radiation therapy for early-stage breast cancer

✍ Scribed by V. Sacchini; K. Beal; J. Goldberg; L. Montgomery; E. Port; B. McCormick

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 185 KB
Volume: 95
Category: Article
ISSN: 0007-1323
DOI: 10.1002/bjs.6208

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Partial breast irradiation has been tested in limited pilot studies and shown to provide acceptable cosmesis, minimal toxicity and adequate local control. The aim of this study was to determine the feasibility of using quadrant high-dose intraoperative radiation therapy (IORT) for the treatment of early-stage breast cancer.

Methods

Fifty-two women with early-stage breast cancer were treated with breast-conserving therapy and IORT between October 2002 and January 2006. The first 18 women received a radiation dose of 20 Gy. The protocol was then amended and the remaining 34 women were treated with 18 Gy. Each patient was evaluated after surgery, and at 3, 6 and 12 months; complications, toxicity and cosmetic outcomes were recorded by the breast surgeon.

Results

Women treated with 18 Gy appeared to have a more favourable cosmetic outcome compared with the earlier treatment group. At last follow-up, none of the women treated on the protocol had a breast recurrence.

Conclusion

Experience suggests that this IORT technique is feasible, although further follow-up is necessary to assess its therapeutic value.

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