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Study of proteolysis of Semax analogues with different N-terminal amino acids by carboxypeptidases

โœ Scribed by K. V. Shevchenko, I. Yu. Nagaev, L. A. Andreeva, L. Yu. Alfeeva, N. F. Myasoedov


Book ID
120964445
Publisher
Springer
Year
2013
Tongue
English
Weight
128 KB
Volume
450
Category
Article
ISSN
0012-4966

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โœ Andersen, Torben P. ;Senning, Alexander ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 608 KB

The newly synthesized amino acid (S)-5-thioxoproline ((sj-Top OH) (1) has been coupled with HCI \* H-(S)-Leu-GlyNRR 6 by the mixed anhydride method. The resulting tripeptide amides (Sy-Top-(Sf-Leu-GlyNRR' 7 are new analogues of the hypothalamic factor MIF. The intermediatcs 6 were synthesiirzd by am