Study of leukocyte kinetics in acute myelocytic leukemia utilizing chromium-51

✍ Scribed by Rosen, Peter J. ;Eyre, Harmon J. ;Lilien, David L. ;Perry, Seymour

• Book ID: 102949686
• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 581 KB
• Volume: 1
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950010108

✦ Synopsis

Abstract

Leukocyte kinetic studies using chromium‐51 were performed in four patients with acute myelocytic leukemia (AML). Intravascular leukocyte survival was prolonged in comparison with granulocyte survival in normal subjects. Significant splenic pooling occurred in three patients, none of whom had splenomegaly. In one patient studied, circulating leukemic cells were shown to return to the bone marrow. The prolongation of intravascular leukocyte survival in AML in relapse, as in chronic myelocytic leukemia, probably depends on several factors including the presence of immature leukemic cells and the recycling of these cells from the spleen and bone marrow.