The interaction between drugs and human serum albumin (HSA) was investigated by capillary electrophoresis (CE). It involves stereoselectivity, drug displacement and synergism effects. Under protein-drug binding equilibrium, the unbound concentrations of drug enantiomers were measured by frontal anal
Study of enantioselective interactions between chiral drugs and serum albumin by capillary electrophoresis
β Scribed by Xiaofeng Zhu; Yongsheng Ding; Bingcheng Lin; Andreas Jakob; Bernhard Koppenhoefer
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 179 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0173-0835
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Capillary electrophoresis frontal analysis was applied to 12 low molecular weight compounds including 8 drug substances displaying a range of different properties with respect to binding affinity, binding location, structure, lipophilicity, charge at physiological pH, and electrophoretic mobility. I
Capillary electrophoresis (CE) is a promising technique for assessment of free bilirubin and its interaction with albumin, as it requires only a small sample volume and provides a rapid and efficient separation of free bilirubin from its albumin-bound complex in a one-phase system. In order to maint