Study of deuterium isotope effects on protein binding by gas chromatography/mass spectrometry. Caffeine and deuterated isotopomers

Study of isotope effects on protein bind

Study of isotope effects on protein binding by gas chromatography/mass spectrometry of theophylline–phenobarbitone and 2H, 13C, 15N isotopomers

✍ Y. Cherrah; J. B. Falconnet; M. Desage; J. L. Brazier; R. Zini; J. P. Tillement 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 452 KB 👁 2 views

We describe a comparative study of human serum albumin (HSA) binding by equilibrium dialysis (pH 7.4, 37 "C, 3 h) for two groups of isotopic analogues: theophylline and 1-C(\*H,)theophylliae; unlabelled, 5(ethyl('H,)), -5(phenyl('H,)) and 1,3-1SN;213C-pbenobarbitone. Bound and free drug fractions ar