Study of an inhibiting factor of epidermal proliferation in plucked skin and various tumours of mice
β Scribed by M. GUIGON; E. FRINDEL; J. HEWITT; M. TUBIANA
- Book ID
- 108654438
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 340 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0007-0963
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## Abstract A fullβthickness cut 7 mm long was made on the middorsal skin of C57BL/10J mice using fine iridectomy scissors. Specimens from the wounded skins were fixed at various days after wounding and were subjected to the dopa reaction and to the combined dopaβpremelanin reaction. In the epiderm
Substance P (SP), fibroblast growth factor (FCF), and epidermal growth factor (EGF) are mitogens for fibroblasts. EGF acts as a progression factor, whereas FGF and SP have competence factor activity. The ability of eicosanoids to regulate proliferation of fibroblasts and the increased production of