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Studies with functionally substituted N-alkylazoles: The reactivity of 1-(3,5-dimethylpyrazol-1-yl)-acetone towards electrophilic reagents

✍ Scribed by Mona Hassan Mohamed; Mohamed Hilmy Elnagdi; Mervat Mohammed Abdel-Khalik

Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
45 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

The reaction of 1‐(3,5‐dimethylpyrazol‐1‐yl)acetone 4 with aromatic diazonium salts afforded the corresponding arylhydrazones 5a,b that were converted into pyridazines 6a,b and 8 via condensation with active methylene nitriles and dimethylformamide dimethylacetal, respectively. Condensation of 4 with phenylhydrazine afforded the phenylhydrazone 10, which could be converted into the indolylpyrazole 11 on treatment with ethanolic hydrochloric acid. Compound 4 also reacted with nitrous acid, benzyl‐idenemalononitrile to yield a variety of substituted new pyrazoles.

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✍ Saleh Al-Mousawi; Seham El-Sherbiny; Elizabeth John; Mervat Mohammed Abdel-Khali 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 69 KB

## Abstract Several new enaminodienones prepared from substituted acetone and dimethylformamide dimethylacetal were used as precursors for synthesis of pyridines, pyranones and benzofurans.