Studies with a human plasma-derived immunosuppressive, anti-lymphoma factor

✍ Scribed by Jeffrey L. Farmer; Morton D. Prager

• Book ID: 104663712
• Publisher: Springer-Verlag
• Year: 1984
• Tongue: English
• Weight: 664 KB
• Volume: 18
• Category: Article
• ISSN: 0340-7004
• DOI: 10.1007/bf00205742

✦ Synopsis

A low-molecular-weight (1,400) factor isolated from a human plasma alpha-globulin concentrate by acid-salt dissociation and ultrafiltration inhibits proliferation of mitogen-stimulated T cells and L1210 leukemia cells. The factor (UM05R) inhibits DNA, RNA, and protein synthesis in sensitive cells, acts in G1 of the cell cycle, and appears to suppress mitogen-responsive T cells without an accessory cell requirement. UM05R activity is enhanced by known cAMP-elevating agents and by sulfhydryl compounds. The results of the present study are consistent with the hypothesis that the plasma-derived agent inhibits lympho-proliferation as a result of elevation of intracellular cAMP.