Molecular imprinting is a technology that allows for the creation of molecular recognition sites in synthetic polymers via the use of templates. Imprinted materials have been used in various applications, including stationary phases for chromatography, recognition elements in sensors, or antibody bi
Studies towards enantioselective surface imprinted polymers
✍ Scribed by Ecevit Yilmaz; Johan Billing; Brian Boyd; Per Möller; Anthony Rees
- Book ID
- 102442816
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 404 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1615-9306
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✦ Synopsis
Abstract
Molecularly imprinted polymers (MIPs) are tailor‐made materials that can specifically rebind desired target molecules. Usually, the template is in solution with monomers that form a specific polymeric cavity around the template. Here, a model system with an amino acid (Fmoc‐L‐Histidine) is presented. This new approach entails the imprinting of templates that are bound to support materials. It is shown that the new approach leads to materials that exhibit symmetric peak shapes for both enantiomers under isocratic conditions.
📜 SIMILAR VOLUMES
Efforts to elucidate the mechanisms underlying the formation of binding sites in molecularly imprinted polymers (MIPs) and of MIP-ligand binding events are presented in the context of a thermodynamic treatment of MIP recognition phenomena.