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Studies toward Total Synthesis of Divergolides C and D

✍ Scribed by Rasapalli, Sivappa; Jarugumilli, Gopalakrishna; Yarrapothu, Gangadhara Rao; Golen, James A.; Rheingold, Arnold L.


Book ID
120173061
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
363 KB
Volume
15
Category
Article
ISSN
1523-7060

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A highly stereocontrolled synthesis of the Cl 1 to C3 1 fragment of the potent antimicrobial agent milbemycin D has been completed. This approach utilizes a unique hydrolysis-cyclization to construct the spiroketal portion of the molecule. The milbemycins 2 and the avermectins3 are two structurall