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Studies on vitamin d (calciferol) and its analogs. IX. lα-hydroxy-3-epivitamin D3: Its synthesis and conformational analysis.

✍ Scribed by William H. Okamura; Marcel R. Pirio

Book ID: 104224248
Publisher: Elsevier Science
Year: 1975
Tongue: French
Weight: 285 KB
Volume: 16
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)91112-2

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✦ Synopsis

Among steroid hormones, la,25-dihydroxyvitamin D3 (l), a metabolite and the presumed active form of vitamin D3 (z), is structurally unique.

3 Unlike the classical steroid hormones such as estrogen, aldosterone, testosterone, etc., the seco-steroid 1 lacks the B-ring.

Recent 1 H NMR studies from this laboratory have shown that the A-ring of l., 4ab as well as that of other related seco B steroids, 4 is partitioned between two rapidly equilibrating chair-like con-

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