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Studies on tumor promoters. 7. The synthesis of a potentially general precursor of the tiglianes, daphnanes, and ingenanes

✍ Scribed by Wender, Paul A.; Lee, Hee Yoon; Wilhelm, Robert S.; Williams, Peter D.


Book ID
120446916
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
574 KB
Volume
111
Category
Article
ISSN
0002-7863

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Studies on tumor promoters. 10. Synthesi
✍ Paul A. Wender; Frank E. McDonald πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier Science 🌐 French βš– 295 KB

A novel synthetic route to the ABC ring system of the daphnanes and tiglianes based on intramolecular enyne carbocyclixation is described that provides access to a new family of diterpene tumor promoter analogs. Phorbol lZmyristate 13-acetate has long been of interest in cancer research as one of th