On the mechanism of the inhibition of gl
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A. Zendedel Haghighi; K. R. Maples
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Article
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1996
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John Wiley and Sons
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English
โ 556 KB
Beta amyloid peptides (AP), etiologically associated with Alzheimer's disease (AD), have been shown to inhibit both glutamine synthetase (GS) and creatine phosphokinase (CPK) in vitro. These two enzymes are affected in AD and are sensitive to oxidative stress. Residue 35 of the AP25-35, the most pot