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Studies on the turnover of glucocerebrosidase in cultured rat peritoneal macrophages and normal human fibroblasts

โœ Scribed by Pijush K. DAS; Gary J. MURRAY; John A. BARRANGER


Book ID
115124344
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
621 KB
Volume
154
Category
Article
ISSN
1432-1327

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Mannose-terminal glucocerebrosidase prepared by exoglycosidase digestion of human placental glucocerebrosidase is reported effective in the treatment of patients with type 1 Gaucher's disease [Barton et al. (1 991 1; N Engl J Med 324:1464-I 4701. However, the amount of enzyme that is necessary for t