𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Studies on the tumor-promoting activity of biomaterials: Inhibition of metabolic cooperation by polyetherurethane and silicone

✍ Scribed by Tsuchiya, Toshie ;Hata, Hideyo ;Nakamura, Akitada

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
561 KB
Volume
29
Category
Article
ISSN
0021-9304

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

When V79 metabolic cooperation (MC) assay was performed to detect tumor‐promoting activities, inhibitory activities on the gap‐junctional intercellular communication were first detected in both extracts prepared from polyetherurethane (PEU) and silicone. The former inhibited more strongly than the latter. Furthermore, the lowest effective concentrations in MC assay correlated well with the values of the total active incidences obtained by histologic evaluation of the 2‐year implantation test in rats. Poly(tetramethylene oxide) (PTMO) showed the highest inhibitory activities among the constituents of PU. Thus, the shorter the chain length of PTMO, the stronger the inhibitory activities of PTMO in MC assay. PTMO moiety may play an important role in the tumor‐promotion stage during tumorigenesis induced by PU. © 1995 John Wiley & Sons, Inc.

📜 SIMILAR VOLUMES

Studies on the tumor-promoting activity
Studies on the tumor-promoting activity of additives in biomaterials: Inhibition of metabolic cooperation by phenolic antioxidants involved in rubber materials
✍ Tsuchiya, Toshie ;Fukuhara, Kiyoshi ;Hata, Hideyo ;Ikarashi, Yoshiaki ;Miyata, N 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 552 KB

## Abstract For the detection of tumor‐promoting activities of phenolic antioxidants, the inhibitory activities on the intercellular gap‐junctional communication were investigated using the V79 metabolic cooperation (MC) assay. Among eight antioxidants, 4,4′‐butylidene‐__bis__(3‐methyl‐6‐__tert__‐b

Studies on the tumor-promoting activity
Studies on the tumor-promoting activity of polyurethanes: Depletion of inhibitory action of metabolic cooperation on the surface of a polyalkyleneurethane but not a polyetherurethane
✍ Tsuchiya, Toshie ;Takahara, Atsushi ;Cooper, Stuart L. ;Nakamura, Akitada 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 577 KB

Methanol extracts prepared from three polyetherurethanes (PEUs), namely PU4, PU6, and PU8, which were synthesized using 4,4'-diphenylmethanediisocyanate, poly(tetramethylene oxide), and 1,4-butanediol, showed an inhibitory action on the gap-junctional intercellular communication in a V79 metabolic c

Studies on tumor-promoting activity of p
Studies on tumor-promoting activity of polyethylene: Inhibitory activity of metabolic cooperation on polyethylene surfaces is markedly decreased by surface modification with collagen but not with RGDS peptide
✍ Nakaoka, Ryusuke ;Tsuchiya, Toshie ;Kato, Koichi ;Ikada, Yoshito ;Nakamura, Akit 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 536 KB

Tumor promotion activity of polyethylene (PE) was estimated in terms of the inhibitory potentials on the gapjunctional intercellular communication using the metabolic cooperation assay. The gap-junctional intercellular communication of test cells was inhibited on the PE film, but this inhibitory act

Studies onin vitro evaluation for the bi
Studies onin vitro evaluation for the biocompatibility of various biomaterials: Inhibitory activity of various kinds of polymer microspheres on metabolic cooperation
✍ Nakaoka, Ryusuke ;Tsuchiya, Toshie ;Sakaguchi, Keisuke ;Nakamura, Akitada 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB

Gap junctional intercellular communication is a function that plays an important role in maintaining cell and tissue homeostasis and in regulating cell growth, development, and differentiation. Change in this function when contacting fibroblasts with various polymer microspheres was estimated using

Studies on the mechanisms of tumorigenes
Studies on the mechanisms of tumorigenesis induced by polyetherurethane in rats: Production of superoxide, tumor necrosis factor, and interleukin 1 from macrophages cultured on different polyetherurethanes
✍ Nakaoka, Ryusuke ;Tsuchiya, Toshie ;Nakamura, Akitada 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 162 KB 👁 2 views

Interaction of macrophages (Møs) with polyetherurethane (PEU) was investigated to clarify the role of the Møs in the early stage of tumorigenesis of PEUs. As for the inflammatory cytokines produced from Møs, the amount of tumor necrosis factor (TNF) produced on three PEUs (PU-4, 6, and 8) was simila