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Studies on the total synthesis of rifamycin. A method for the stereospecific synthesis of the carbonyl-conjugated 1,3-diene unit [C(15) to C(20)]

✍ Scribed by E.J. Corey; Greg Schmidt


Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
280 KB
Volume
20
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


Studies on the total synthesis of rifamy
✍ E.J. Corey; David A. Clark πŸ“‚ Article πŸ“… 1980 πŸ› Elsevier Science 🌐 French βš– 204 KB

The formation of the macro ring of rifamycin S (4) has been accomplished by generating the lactam linkage through cyclization of a suitably protected and activated amino acid (4). 1 Previous papers from these laboratories on the synthesis of rifamycin S (1) have dealt with 2 in 80% yield occurs unde

Studies on the total synthesis of rifamy
✍ E.J. Corey; Tapio Hase πŸ“‚ Article πŸ“… 1979 πŸ› Elsevier Science 🌐 French βš– 235 KB

One interesting possibility for the elaboration of the C(15) to C(29) chain of the antibiotic rifamycin S (l)l is illustrated by the antithetic relationship indicated in Scheme I. In this plan the ry SCHEME I 3 intermediate zwhich corresponds to the C(19) to C(27) chain is disconnected to a bifuncti

Studies directed towards the total synth
✍ Robert E Ireland; Peter Wipf πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 254 KB

The protected C(1) to C(15) segment of FK-506 has been prepared from D-glucose, glycolic and L-pipecolic acid. The novel, highly active immunosuppressive agent FK-506 (1) has attracted considerable attention.1 The biological potency as well as some unique structural features render this 23-membered

A short synthesis of the C15–C21 segment
✍ Kazi A. Shahid; Yong-Nan Li; Momotoshi Okazaki; Yoshihiro Shuto; Fumitaka Goto; πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 136 KB

A new approach was developed to versatile enantiopure stereotriads using chiral oxazaborolidinone-promoted asymmetric aldol reaction of a racemic aldehyde with a bromo silyl nucleophile. A short synthesis of the C 15 -C 21 segment of (+)-discodermolide was achieved by elongation of one of the stereo