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Studies on the synthesis of chemotherapeutics. 12. Synthesis and antitumor activity of N-phthalidyl-5-fluorouracil derivatives

✍ Scribed by Kametani, Tetsuji; Kigasawa, Kazuo; Hiiragi, Mineharu; Wakisaka, Kikuo; Nakazato, Kikuo; Ichikawa, Keiko; Fukawa, Kazunaga; Irino, Osamu; Nishimura, Naoyuki; Okada, Taiji

Book ID: 111918008
Publisher: American Chemical Society
Year: 1982
Tongue: English
Weight: 519 KB
Volume: 25
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00352a024

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## Synthesis and Antitumor Activities of 1-Carbamoyl-5-fluorouracils. -Fifty-four derivatives of (I) are synthesized from 5-fluorouracil and isocyanate or amine. Compound (Ib) gives the best results in antitumor activity tests. -(OZAKI, S.; KONG, X.;