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Studies on the Synthesis and Properties of Temperature Responsive and Biodegradable Hydrogels

✍ Scribed by Li-Fang Sun; Ren-Xi Zhuo; Zhi-Lan Liu

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
75 KB
Volume
3
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Novel linear poly(NIPA‐co‐CL) copolymers have been synthesized by radical copolymerization of N‐isopropylacrylamide (NIPA) and 2‐methylene‐1,3‐dioxepane (MDO). The structure of copolymers was confirmed by ^1^H NMR and IR spectroscopy. Cross‐linked poly(NIPA‐co‐CL) hydrogels have also been prepared in toluene using N,N′‐methylenebisacrylamide as cross‐linking agent. The hydrogels thus obtained exhibit good temperature response and are biodegradable in the presence of proteinase K.

Temperature influence on the enzymatic degradation by proteinase K of poly(NIPA‐co‐CL) hydrogel (G‐60).

magnified imageTemperature influence on the enzymatic degradation by proteinase K of poly(NIPA‐co‐CL) hydrogel (G‐60).

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