Studies on the sub-banding of creatine kinase MM and the “CK conversion factor”
✍ Scribed by H. Falter; L. Michelutti; A. Mazzuchin; W. Whiston
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 535 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0009-9120
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✦ Synopsis
In serum, the M subunit of creatine kinase (CK) isoenzymes, MM and MB, is modified by a heat labile factor. As a result of the modification three sub-bands of MM and two of MB can be demonstrated by agarose electrophoresis. Normal sera contain MMI as the dominant sub-band with lesser amounts of MM2 and MM3. Following tissue damage the MM sub-band distribution changes as a result of the increased release of MM, which occurs as MM3. Immediately after coronary bypass surgery MM3 is the dominant sub-band to be replaced by MM2 and in turn by MMI. The factor responsible for the modification of the M subunit, the "CK conversion factor" has been partially purified and its
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