## Abstract The 7‐deaza‐2′‐deoxy‐7‐methylguanosine (2b) [9], which is the glycosylic‐bond‐stable, noncharged analogue of 2′‐deoxy‐7‐methylguanosine (1b), was incorporated in DNA by solid‐phase synthesis. As building blocks, the protected phosphonatc 3a and the phosphoramidite 3b were prepared. The
Studies on the structure of chemically methylated DNA
✍ Scribed by E. Bauer; H. Berg; G. Löber; K. Weller; M. Hartmann; Ch. Zimmer
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- English
- Weight
- 963 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0301-4622
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📜 SIMILAR VOLUMES
## Synopsis Methylation of phosphate groups in oligo-dT strands leads to a parallel duplex with T . T base pairs. Molecular mechanics calculations on parallel d ( l T M T T ) , show it to be a symmetric right-handed helix with B-DNA conformational characteristics. Phosphate methylation stabilizes
Contrary to mammalian DNA, which is thought to contain only 5-methylcytosine (m5C), bacterial DNA contains two additional methylated bases, namely N6-methyladenine (m6A), and N4-methylcytosine (m4C). However, if the main function of m5C and m4C in bacteria is protection against restriction enzymes,