✦ LIBER ✦
Studies on the structural feature of S'1 subsite of neprilysin (EC.3.4.24.11): Stereochemical requirement for the enzyme-inhibitor docking process
✍ Scribed by Denis Danvy; Thierry Monteil; Jean-Christophe Plaquevent; Lucette Duhamel; Pierre Duhamel; Claude Gros; Nadine Noël; Jean-Charles Schwartz; Jeanne-Marie Lecomte
- Book ID
- 103983574
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 187 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
✦ Synopsis
The preferred conformation of thiorphan during the inhibitor-neprilysin docking process was investigated. A series of achiral inhibitors were tested. This study led to the design of a potent inhibitor, in which the ethylenic bond bears the aryl residue of P'I.