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Studies on the stability of vinblastine sulfate in aqueous solution

โœ Scribed by Jimmy Black; Douglas D. Buechter; John W. Chinn; John Gard; David E. Thurston

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
647 KB
Volume
77
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

A stability study on vinblastine sulfate (1) in aqueous solution at several different temperatures (in the absence of light) has been undertaken. High-performance liquid chromatography was used to obtain kinetic data for,the loss of vinblastine and to monitor the order of appearance of degradation products, of which eight were observed. The two most prominent components of early heat degradation have been tentatively identified by mass spectrometry (DCI), as a C19'-oxidation

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