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Studies on the sleep-promoting mechanisms mediated by adenosine A2A receptors

✍ Scribed by S. Satoh; N. Koike; O. Hayaishi


Book ID
117365041
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
127 KB
Volume
31
Category
Article
ISSN
0168-0102

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A step-wise CoMFA-based procedure was applied to a series of 51 C2-oxyadenosines in order to select the most predictive conformation for binding to A 2A adenosine receptor. The highest correlation and predictive power was found for conformers with the side chain at the 2position oriented in the dire