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Studies on the ring opening reactions of 3-oxa-1-azabicyclo[3.1.0]hexan-2-ones. Synthesis of aminomethyl oxazolidinones and aziridinyl ureas

โœ Scribed by Greggory M. Wells; Travis Dudding; Lee Belding; Jeffery A. Frick; Abhijit Nayek; Junfeng Huang; Steven J. Katz; Stephen C. Bergmeier


Book ID
113929408
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
424 KB
Volume
68
Category
Article
ISSN
0040-4020

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1-Chlorocyclopropyl p-tolyl sulfoxides bearing an alkoxymethyl group at the 2-position were easily prepared from a,b-unsaturated esters with dichloromethyl p-tolyl sulfoxide and alkylhalides in three steps in good overall yields. Treatment of the 1-chlorocyclopropyl p-tolyl sulfoxides with i-PrMgCl