Inactivation of p27Kip1 promotes chemica
Inactivation of p27Kip1 promotes chemical mouse liver tumorigenesis in the resistant strain C57BL/6J
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Daqian Sun; Hao Ren; Michael Oertel; Rani S. Sellers; David A. Shafritz; Liang Z
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Article
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2007
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John Wiley and Sons
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English
β 408 KB
## Abstract The biochemical function of p27Kip1 as an inhibitor of cyclinβdependent kinases is wellβestablished, but the role of p27 as a tumor suppressor depends on specific cellular contexts. Previous studies using p27 knockout mice on mixed C57BL/6JβΓβ129/Sv strain background did not find a tumo