Linkage studies in families with presenile onset of Alzheimer's disease (AD) indicated the presence of a predisposing gene on the proximal long arm of chromosome 21. We mapped four new loci in the candidate AD region using somatic cell hybrids. For three of the four loci, several restriction fragmen
Studies on the polymorphism of C3, Tf and Bg in Down's syndrome and other diseases
✍ Scribed by D. P. Agarwal; L. M. Srivastava; H. G. Benkmann; H. W. Goedde; P. Grünwald
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 344 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
The distribution of phenotypes C3, Ff and Bg was investigated in sera of patients with Down's syndrome, oligophrenia, Wilson's disease and heart infarct. Quantitative determination of the concentration of C3 and C4 components of human complement was also carried out in these patients. The results are compared to healthy controls and are discussed with already reported data from other authors. Despite differences in the percentage distribution of various phenotypes in the patients' sera as compared to that of the controls, no statistically significant association could be established.
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The morning session consists of two keynote speakers and 8 presentations by the following individuals with allotted time for questions and answers after each presenter.