Studies on the Physicochemical Properties, Structure and Antitumor Activity of Polysaccharide YhPS-1 from the Root of Cordalis yanhusuo Wang

✍ Scribed by Yi-Wen Tao; Geng-Yuan Tian

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 64 KB
• Volume: 24
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200690045

✦ Synopsis

Abstract

A polysaccharide named YhPS‐1 was isolated from the root of Cordalis yanhusuo Wang and purified by means of gel‐permeation chromatography and ionexchange chromatography. Its physicochemical properties, including monosaccharide composition, carbohydrate content, molecular weight and elemental composition, were determined. The structure of YhPS‐1 was elucidated by chemical methods along with ^1^H and ^13^C NMR spectroscopy ways, such as including two‐dimensional HMQC and HMBC experiments. These results show that YhPS‐1 possesses a backbone consisting of terminal α‐Glc__p__‐(1→, α‐Glc__p__‐(1→6), α‐Glc__p__‐(1→4) and α‐Glc__p__‐(1→4,6). The bioactive assay showed that it could inhibit the growth of Sarcoma 180 and Lewis pulmonary carcinoma implanted in mice.