Studies on the phase transitions of lysoderivatives of ethanolamine glycerophospholipids from human brain

✍ Scribed by Johannes Gunawan; Achim Harder; Hildegard Debuch

• Publisher: Elsevier Science
• Year: 1986
• Tongue: English
• Weight: 318 KB
• Volume: 39
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(86)90106-4

✦ Synopsis

The phase transition temperature of 1,2-distearoylglycerophosphocholine is reduced in presence of equimolar amounts of 1-O-(le-alkenyl)-glycerophosphoethanolamine (ethanolamine lysoplasmalogen) from 53.3°C-54.1°C to 44.0°C-44.9°C at different pH (4.0; 7.2; 9.0; 10.5). 1-Acyl-glycerophosphoethanolamine leads to a smaller reduction of the 1,2-distearoyl-glycerophosphocholine transition temperature: 45.0°C-46.2°C at the same pH-values.

1-Alkyl-glycerophosphoethanolamine (hydrogenated ethanolamine lysoplasmalogen)possesses a transition temperature, which is 3.3°C-4.9°C higher than the hydrogenated 1-acylglycerophosphoethanolamine at each pH investigated. At pH 9.0 and, more pronounced, at pH 10.5 we find a reduction of the transition temperature for both these substances, whereas their transition temperature is nearly unchanged at pH 4.0 and 7.2. Our results clearly show that the ether-bonding in the lysoderivative of plasmalogen is responsible for the closer packing compared to the 1-acyl-glycerophosphoethanolamine.