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Studies on the mechanism by which indomethacin increases the anticancer effect of methotrexate

โœ Scribed by A. Bennett; J.D. Gaffen; P.B. Melhuish; I.F. Stamford

Book ID
117958604
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
1009 KB
Volume
91
Category
Article
ISSN
0007-1188

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## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^โˆ’1^) during a continuous MTX infusion (1ยท2 mg kg^โˆ’1^) over 240 min. IND was injected i.v. at hourly intervals after a steady