Studies on the maturation of thymus stem cells The effects of catecholamines, histamine and peptide hormones on the expression of T cell alloantigens
β Scribed by Upendra Singh; J. J. T. Owen
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 391 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0014-2980
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β¦ Synopsis
Abstract
Studies have been performed in order to investigate the effects of catecholamines, histamine, peptide hormones and various other agents known to increase cellular adenosine 3β²:5β²βcyclic monophosphate (cAMP) levels, on the expression of Thyβ1 and TL antigens on 14βday fetal thymic stem cells. It has been shown that the proportions of Thyβ1 and TL positive cells, as detected by dye exclusion cytotoxicity tests, can be significantly increased by some of these agents and that these effects may be inhibited by Ξ² adrenergic and H2 antagonists. The value of these tests as a means for studying normal thymic stem cell maturation and for investigating T cell deficiency is discussed.
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