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Studies on the maturation of thymus stem cells The effects of catecholamines, histamine and peptide hormones on the expression of T cell alloantigens

✍ Scribed by Upendra Singh; J. J. T. Owen


Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
391 KB
Volume
6
Category
Article
ISSN
0014-2980

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✦ Synopsis


Abstract

Studies have been performed in order to investigate the effects of catecholamines, histamine, peptide hormones and various other agents known to increase cellular adenosine 3β€²:5′‐cyclic monophosphate (cAMP) levels, on the expression of Thy‐1 and TL antigens on 14‐day fetal thymic stem cells. It has been shown that the proportions of Thy‐1 and TL positive cells, as detected by dye exclusion cytotoxicity tests, can be significantly increased by some of these agents and that these effects may be inhibited by Ξ² adrenergic and H2 antagonists. The value of these tests as a means for studying normal thymic stem cell maturation and for investigating T cell deficiency is discussed.


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