Studies on the macrolides from marine dinoflagellate Amphidinium sp.: Structures of amphidinolides R and S and a succinate feeding experiment

✍ Scribed by Masami Ishibashi; Miho Takahashi; Jun'ichi Kobayashi

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 388 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(97)00473-0

✦ Synopsis

Two new cytotoxic macrolides, amphidinolides R (1) and S (2), were isolated from the cultured marine dinoflagellate Amphidinium sp. and their structures including absolute configuration were elucidated on the basis of spectroscopic data as well as chemical experiments. In a feeding experiment of 13C-labeled succinic acid into a culture of Amphidinium sp., no enrichment of the 13C NMR signal intensity of any carbon of amphidinolide J

(3), the most abundant macrolide in this dinoflagellate, was observed.