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Studies on the lysis of red cells and bimolecular lipid leaflets by synthetic lysolecithins, lecithins and structural analogs

โœ Scribed by F.C. Reman; R.A. Demel; J. De Gier; L.L.M. Van Deenen; H. Eibl; O. Westphal


Book ID
103039268
Publisher
Elsevier Science
Year
1969
Tongue
English
Weight
494 KB
Volume
3
Category
Article
ISSN
0009-3084

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โœฆ Synopsis


The results obtained m this study show a great influence of the acyl cham on the lyhc behawor of lysoleclthlns and leclthms 1 The lysolectthlns studied, ranged m acyl chain length from 10 to 18 carbon atoms

The palmato)l-and stearoylder~vat~ves were found to be the most active, whereas the shortcham compounds hke decanoyl-lysolectthm showed no activity at all

The possible influence of the glycerohc hydroxylgroup was studied by means of 8 different desoxy-lysoleclthms, '~arymg m chain length from 12 to 26 carbon atoms Thts structural modification, however, turned out to be neghg~ble The highest act~wty was also found for compounds with 16 and 18 carbon atoms, while the shorter and longer chain ones (lauroyl C12, myrlstoyl C14, arach~doyl C20) ~ere less actl~ e, or not achve at all (behenoyl C26, cerotoyl C22)