Studies on the kinetics of cell respiration. Oxidation of pyruvic acid by E. Coli, PS. Pyocyaneus, staph. Aureus and saccharomyces cerevisiae

✍ Scribed by Chen, H. K. ;Tang, P. S.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1940
• Tongue: English
• Weight: 404 KB
• Volume: 16
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030160305

✦ Synopsis

Three hypotheses on the mechanism of aerobic oxidation of pyruvic acid are available at present, namely, (1) the acid is oxidized directly to aleetic acid and carbon dioxide with the aid of "a-keto-oxidase" (Barron and Miller, '32) :

(2) The acid is first converted into acetaldehyde by the action of carboxylase, and the resulting acetaldehyde is further oxidized to acetic acid (Cedrangolo, '37) : CH,. CO. COOH = CH,. CHO + CO, CH,. CHO + + O2 = CH,. C O O H

( 3 ) IPyruvic acid is first converted into carbon dioxide, lactic and acetic acids through dismutation. The lactic acid is subsequently oxidized to pyruvic acid (Krebs, '37