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Studies on the grignard reactions III. competitive addition-reduction in the reaction of 2,4-dimethyl-3-pentanone with the grignard reagent from bromopropane.

โœ Scribed by M.J. Anteunis; R. D'Hollander

Publisher
Elsevier Science
Year
1962
Tongue
French
Weight
250 KB
Volume
3
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Th8 competitive addition-reduction of 2,kdlmethyl-3-pento rith %.PrHgRra vas studied using the procedure described earlier'.

The reaction vas followed by quantitative vapour pba8e chromatogra phY2 analysis of the products. The Grlgnard reagent was prepared by reaction of n.propylbromlde vlth magne-81~~ In ether; and the exce88 MgBr2 vas determined a8 being the dlfferenee between a Volhard titration and a new method bared on the reaction of the Grlgnard reagent ulth benzophe-non8 (to be publirhed). Moxane ~88 added until both ana-~~18 method8 gave the 88me result. wlraa the reagent was In large excess (t (nPr)#g&gBr2 = 0.579; t ketone = O&72) the ratio of addition compound (2aethgrl-3-lropro~l-3-hexanol) to reduction compound (2&-dlme-' Part I. M. Anteunls, J.Om.Chem. Part 11. H. Anteunis, J.Oz?g.Chem. ' The Instrument ased was a A-350-B a disc Integrator. 1275 a6, 4& (1961). a, 596 (1962).

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