𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Studies on the genetic regulation of cytochrome P-450 production in Saccharomyces cerevisiae

✍ Scribed by King, D. J. ;Wiseman, A. ;Wilkie, D.

Publisher
Springer
Year
1983
Tongue
English
Weight
530 KB
Volume
192
Category
Article
ISSN
0026-8925

No coin nor oath required. For personal study only.

✦ Synopsis

An initial survey of 18 haploid strains of Saccharomyces cerevisiae revealed that only 3 of these strains could produce a detectable level of cytochrome P-450. A cross between a cytochrome P-450 producing strain of S. cerevisiae (B/B) and a non-producing strain (D22) gave a diploid which was a non-producer and a 2:2 segregation of producers to non-producers in meiotic tetrads. Of the two producers in each tetrad, one produced a higher level of cytochrome P-450 than the other. We deduce that cytochrome P-450 production in S. cerevisiae is regulated by a single nuclear gene and that a modifier gene is also involved which can enhance the amount of cytochrome P-450 synthesized. Benzo(a)pyrene (an inducer of P-450 in yeast) had no effect on the action of the regulatory gene.

πŸ“œ SIMILAR VOLUMES

The cytochrome oxidase subunit I split g
The cytochrome oxidase subunit I split gene in Saccharomyces cerevisiae: Genetic and physical studies of the mtDNA segment encompassing the β€˜cytochrome b-homologous’ intron
✍ Netter, Pierre ;Carignani, Giovanna ;Jacq, Claude ;Groudinsky, Olga ;Clavilier, πŸ“‚ Article πŸ“… 1982 πŸ› Springer 🌐 English βš– 857 KB

We have constructed a refined genetic and physical map of 38 oxi3 mutations. With the help of the rho- clones derived from 'short' and 'long' genes, pairwise crosses between mutants, estimations of their reversion frequencies and analyses of mitochondrially synthesized proteins, we have characterize

Regulation of the ilv 1 multifunctional
Regulation of the ilv 1 multifunctional gene in Saccharomyces cerevisiae
✍ Bollon, Arthur P. πŸ“‚ Article πŸ“… 1975 πŸ› Springer 🌐 English βš– 760 KB

The ilv 1 gene in S. cerevisiae codes for a regulatory protein involved in depression of the ilv 2 and ilv 3 genes as well as a biosynthetic enzyme, threonine deaminase. 2. The ilv 1 gene does not autogenously regulate its catalytic product threonine deaninase. 3. Regulation of the ilv 2 and ilv 3 g

Studies on the interaction of furan with
Studies on the interaction of furan with hepatic cytochrome P-450
✍ Parmar, Devendra ;Burka, Leo T. πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 869 KB

In vitro incubation of rat liver microsomes with ['4C]-furan in the presence of NADPH resulted in the covalent incorporation of furan-derived radioactivity in microsomal protein. Compared to microsomes from untreated rats a two-to threefold increase in binding was observed with microsomes from pheno