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Studies on the epimerization of diastereomeric lactides

✍ Scribed by Ivan A. Shuklov; Haijun Jiao; Joachim Schulze; Wolfgang Tietz; Klaus Kühlein; Armin Börner

Book ID: 104098787
Publisher: Elsevier Science
Year: 2011
Tongue: French
Weight: 288 KB
Volume: 52
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.12.094

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✦ Synopsis

The epimerization of chiral lactides was studied in the presence of various homogeneous and heterogeneous bases. Some solvent/base systems were found to promote epimerization at room temperature efficiently. Side reactions such as polymerization were not observed or occurred only slowly. This new protocol offers the opportunity of the transformation of meso-lactide into rac-lactide. Therefore it can reduce the overall manufacturing costs of polylactides, a problem which currently hampers the broad application of those environmentally friendly polymers in a large scale.

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