Studies on the effect of ethanol and/or toluene on rat erythrocytes

✍ Scribed by Janusz Rosin; Grzegorz Bartosz; Teresa Wrońska-Nofer

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 344 KB
• Volume: 8
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550080506

✦ Synopsis

t o d i . and .'*Department o f Biophysics. University of L 6 d i . 90-237 t c i d i , Poland Key words: toluene, ethanol. red blood cells. macrocytosis, lipid fluidity Rats were subjected to a chronic ethanol exposure in their drinking water for 8 months and then a short subacute toluene exposure to 12 000 m g h ' for 5 h/day for nine days. Combined exposure increased the reticulocyte count and the concentration of haemoglobin, and changed the biochemical/biophysical properties of red blood cells. Macrocytosis and a decrease in erythrocyte membrane lipid fluidity in the middle zone of the lipid bilayer were the most useful indices of exposure.