The objective of this study was: (1) to characterize the P-gp inhibitory effect of different concentrations of Pluronic P85 on anti-HIV-1 drug cellular accumulation, and (2) to investigate the relationship between cellular accumulation and free fraction of drug. Cellular accumulation studies in MDCK
Studies on the Effect of Cell Division-inhibiting Herbicides on Unialgal and Mixed Algal Cultures
✍ Scribed by Dr. Vince Ördög; Kaija Kuivasniemi
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 345 KB
- Volume
- 74
- Category
- Article
- ISSN
- 1434-2944
No coin nor oath required. For personal study only.
✦ Synopsis
The effect of two cell division inhibiting herbicides on unialgal and mixed algal cultures was st)irdird in laboratory tests. The herbicides studied were trifluralin (analytical grade) and the activc ingredient a s well as the preparation (80 0 , ' " a.i.) of diphenamid. The three green algal species used were Seleuastrurn cupricornuturn PRINTZ, Scenedesmus quadricauda (TuRP.) BREB., Ooeysfis jmrva, W. e t G. S. WEST. The response of algae to herbicides was determined by cell count,ing, and measured by turbidity (750nm) and the 02-production of some of the treated cii 1 tures.
The EC,(,-value (96 11) of trifluralin to Selenastrum cnpricornutum was 3.3 mgil. There were differences in the sensitivit,y of t,he three algal strains to the diphenamid; the ECBo-values to b"ekwastruwt, Scenedesmus and Oocystis were 16.7, 10.1 and 6.3 mg/l, respectively. The lag phase observed in the growth of the t,reated cultures caused by diphenamid was verified by 02-measuremcnts. The preparation of diphenamid was not as effective as the active ingredient. In mixed cult,ures the ratio between two different algal strains depended both on the concentration of the diphenamid and the sensitivity of the two strains.
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