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Studies on the conversion of 3,3-dimethyl-2-butanone into geminal isocyano tosyl alkenes

โœ Scribed by Daan van Leusen; Albert M. van Leusen


Book ID
104589359
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
317 KB
Volume
110
Category
Article
ISSN
0165-0513

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High Yield Synthesis of Filicinic Acid,
โœ L. De Buyck; N. De Kimpe; R. Verhรฉ; N. Schamp ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Wiley (John Wiley & Sons) โš– 309 KB ๐Ÿ‘ 2 views

## Abstract Filicinic acid (5) was prepared in 75โ€80% overall yield from 4,4โ€dimethylโ€2โ€cyclohexenone (1). The key intermediate, tetrachlorodienone 2, underwent facile substitution of both ฮฒโ€chlorine substituents by methoxide affording the bis enol ether 3 which was converted into dichlorofilicinic