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The development of a rational approach to research on the chemotherapy of virus infections is beset with many difficulties. These agents of disease all multiply intracellularly and little is known regarding the mechanism of their patbogenesis. Furthermore, apparently lacking independent enzyme systems, their metabolism appears to be intimately associated with that of the host cell (Hoagland, C. L., Ward, S. M., Smadel, J. E., and Rivers, T. M., Journal of ]~:xperimental Medicine, 76: ~63, I942). Indeed their only attribute of life, in the commonly accepted meaning of the term, is the ability to reproduce, and even here the energy and organization of the host cell is necessary. Consequently it is not surprising that they have proved refractory to the antibiotics, sulfonamides and other chemotherapeutic agents which have been so effective in combatting bacterial and protozoan infections (Findlay, G. M., "Recent Advances in Chemotherapy," 2nd Ed.,
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The effects of arterial infusion with chemotherapy alone or in combination with hepatic artery ligation on the normal liver of the cat were studied. Early in the course of treatment cats receiving chemotherapy infusion only appeared sicker than animals in other groups. Yet only 1 of 5 cats was dead