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Studies on the aetiology of bilharzial carcinoma of the urinary bladder VI. Beta-glucuronidases in urine

✍ Scribed by G. A. Abdel-Tawab; S. M. El-Zoghby; Y. M. Abdel-Samie; A. Zaki; A. A. Saad

Publisher: John Wiley and Sons
Year: 1966
Tongue: French
Weight: 444 KB
Volume: 1
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910010410

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✦ Synopsis

The p H specificity of B-glucuronidase enzymes in the urine of cancerous and noncancerous bilharzial patients was investigated.

Bilharzial patients with urine pH above 6.0 and bilharzial bladder cancer patients had heterogeneous urinary B-glucuronidase activities with distinct p H optima of 5.0 and 7.0, whereas other bilharzial patients and controls showed only the former peak. W e suggest that the urinary B-glucuronidase with a p H optimum of 7.0 is of bacterial origin. This enzyme may also influence the liberation of bladder carcinogens from their excreted glucuronide conjugates.

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