Studies on the Adsorption of Sulfapyridine at the Solution–Alumina Interface

✍ Scribed by A.K. Bajpai; M. Rajpoot; D.D. Mishra

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 199 KB
• Volume: 187
• Category: Article
• ISSN: 0021-9797
• DOI: 10.1006/jcis.1996.4655

✦ Synopsis

imizing the bacterial infection. Keeping in mind the pre-The adsorption of Sulfapyridine (SP) onto the alumina surface viously mentioned useful aspect of adsorption of sulfanilhas been carried out at room temperature to study the adsorption amide and extending our previous works on adsorption of behavior of SP and its mode of interaction with the surface of polymer (9, 10), proteins (11, 12), and sulfonamides (13, alumina particles. It is found that various factors such as concen-14) onto solids, we are reporting the results of adsorption tration of SP solution, required time for adsorption equilibrium, of sulfapyridine (SP) on alumina in the present investigation. pH of the adsorbate solution, temperature of adsorption medium, Such adsorption studies of sulfa drugs may also exploited presence of ions like PO 30 4 , SO 20 4 , and Cl 0 affect quantitatively when studying the techniques of the separation sciences like the adsorption of SP. Various adsorption and kinetic parameters column chromatography. such as the adsorption isotherm, adsorption coefficient, rate constants for adsorption and desorption and surface coverage have also been evaluated. The present study is significant because MATERIALS AND METHOD knowledge of the exact interaction between the SP molecules and the alumina surface and the proper choice of experimental condi-Materials tion would be helpful in carrying out an optimum separation of sulfa drug compounds chromatographically.