✦ LIBER ✦
Studies on Taxol® biosynthesis. Preparation and tritium labeling of biosynthetic intermediates by deoxygenation of a taxadiene tetra-acetate obtained from Japanese yew
✍ Scribed by Tohru Horiguchi; Christopher D. Rithner; Rodney Croteau; Robert M. Williams
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- French
- Weight
- 218 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
Taxa‐4(20),11(12)‐diene‐5__α__‐acetate 5 and taxa‐4(20),11(12)‐diene‐5__α__‐acetate, 10__β__‐ol 6, have been identified as early stage intermediates involved in the biosynthesis of Taxol^®^ (paclitaxel). Tritium‐labeled 5 and 6 were successfully prepared by Barton deoxygenation using tri‐n‐butyltintritiide of the C‐14‐hydroxyl group of a taxoid obtained from Japanese yew. Copyright © 2008 John Wiley & Sons, Ltd.