Studies on rifamycin production by Amycolatopsis mediterranei cells immobilized on glass wool

✍ Scribed by Mohamed R. Abu-Shady; Ahmed I. El-Diwany; Dr. Mohamed A. Farid; Hesham A. El-Enshasy

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 362 KB
• Volume: 35
• Category: Article
• ISSN: 0233-111X
• DOI: 10.1002/jobm.3620350502

✦ Synopsis

Cells of Amycolatopsis mediterranei CBS 42575 were immobilized on glass wool for the production of rifamycins B and SV. Glass wool (CORNING type) of 8 microns in diameter has a better entrapment capacity for microbial cells of microorganism than the other types of glass wool used. The most suitable amount of glass wool was 0.8 g/50 ml. The best initial cell concentration used as inoculum was 40 mg cells/50 ml. Repeated batch production of rifamycins by immobilized cells on glass wool was carried out for 6 repeated batches. The results showed that reduction of batch time from 96 h to 48 h does not decrease rifamycin production by immobilized cells.