Studies on quinazolines. 6. Asymmetric synthesis of (S)-(+)- and (R)-(−)-3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-5-methylthio-2,3-dihydroimidazo[1,2-c]quinazolines
✍ Scribed by Gutcait Alexander; Wang Kuang-Chao; Liu Hsiu-Wen; Chern Ji-Wang
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 480 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
No coin nor oath required. For personal study only.
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## Abstract The reaction of 3‐__N__‐(2‐mercapto‐4‐oxo‐4__H__‐quinazolin‐3‐yl)acetamide (**1**) with hydrazine hydrate yielded 3‐amino‐2‐methyl‐3__H__‐[1,2,4]triazolo[5,1‐__b__]quinazolin‐9‐one (**2**). The reaction of **2** with __o__‐chlorobenzaldehyde and 2‐hydroxy‐naphthaldehyde gave the corresp